Mycotoxins are toxic and carcinogenic metabolites of low molecular weight that are produced by certain species of fungi and pose one of the greatest threats for the safety and quality of food and feed. Mycotoxins are able to contaminate food and animal feed causing acute or chronic toxicity on humans and animals. The losses of foods due to mycotoxins and the expenses for their management have increased dramatically worldwide. Remarkable is the fact that more than 25% of agricultural products are contaminated annually with mycotoxins worldwide (FAO). Most of the mycotoxins are very stable and cannot be degraded during the processing of the agricultural products. Similarly, the presence of these toxins in feed can have as a result their transport to animal products that are intended for human consumption resulting in severe consequences for the human health even death. So, it is common that there is a continuous risk of mycotoxins “from the farm to the fork”. It is also foreseen that climate conditions and/or production practices may have an impact by favoring growth of mycotoxigenic fungi and consequently mycotoxin production. The European Union legislation is very strict on the presence of mycotoxins in various products and makes imperative the discovery of effective solutions. The economically effective solutions are those that with the help of agricultural precision technology and knowledge will contribute to the exclusion of fungi from the plant-host and/or the restriction of mycotoxin production in their hosts or downstream to the production line with the help of an Integrated Pest Management (IPM) system that will be friendly and sustainable for the environment.